Wound biofilms: Lessons learned from oral biofilms

Control of oral biofilms.

Oral biofilms play a major role in the etiology of oral diseases, and have broad implications for quality of life, systemic health and economic costs. Hypotheses regarding the mechanisms by which oral biofilms exert their pathogenic potential have evolved over time. Early theories in which oral diseases were associated solely with the quantity of colonizing biofilms have been replaced by the un...

Red and Green Fluorescence from Oral Biofilms

Red and green autofluorescence have been observed from dental plaque after excitation by blue light. It has been suggested that this red fluorescence is related to caries and the cariogenic potential of dental plaque. Recently, it was suggested that red fluorescence may be related to gingivitis. Little is known about green fluorescence from biofilms. Therefore, we assessed the dynamics of red a...

Candida Biofilms on Oral Biomaterials

Antibiofilm peptides against oral biofilms

The oral cavity is a major entry point for bacteria and other microorganisms. Oral biofilms are formed by mixed communities of microorganisms embedded in an exopolysaccharide matrix. Biofilms forming on dental hard or soft tissue are the major cause of caries and endodontic and periodontal disease. Human oral biofilms exhibit high resistance to antimicrobial agents. Antibiofilm peptides constit...

Chronic Wound Colonization, Infection, and Biofilms

The term “chronic wound” is generally accepted, but yet no simple definition has been agreed upon. A mechanistic definition such as “those not following normal wound healing trajectory” have been proposed but the most common definition have been “ulcers (wounds) older than 3 months of age”. Indeed, some ulcers have been present for years. One to two percent of the population in the developed co...